(MEMPHIS, Tenn. – April 25, 2024) Medulloblastoma (the most common malignant childhood brain tumor) is separated into four molecular groups, with Group 3 bearing the worst prognosis. By studying EP300 and CBP, critical proteins in Group 3 medulloblastoma cells, scientists at St. Jude Children’s Research Hospital designed a way to enhance anti-tumor activity by targeting a specific part of these proteins. This targeted approach significantly reduced cancer cell growth. The findings were reported today in Nature Communications.
Previous research by St. Jude scientists and others has classified medulloblastoma into four distinct molecular groups: WNT and SHH — driven by their namesake genetic mutations — Group 3 and Group 4. The prognosis for medulloblastoma is different for each molecular group. Retrospective analyses have shown that WNT tumors have 95% five-year survival. SHH and Group 4 tumors have approximately 75% five-year survival, and the survival rate for Group 3 is only 60%. Approximately one-third of all patients with medulloblastoma relapse, but the rate of relapse varies based on factors such as the patient’s age and what type of therapy they receive.
Source: Targeting specific protein regions offers a new treatment approach in medulloblastoma
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